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Targeting Central Plasticity: A New Direction of Finding Painkillers

[ Vol. 11 , Issue. 21 ]


Min Zhuo   Pages 2797 - 2807 ( 11 )


It is well documented that sensory transmission, including pain, receives endogenous inhibitory modulatory influences at dorsal horn of the spinal cord. Recent results, from behavioral to molecular studies, demonstrate that injury caused plastic changes in forebrain areas. In addition to encoding pain, these supraspinal areas may also affect pain transmission in the spinal cord level by activating “top-down” descending facilitatory systems. In this review, I provide review of evidence related to these new progresses, from human brain imaging to work from genetically mutant mice.


plasticity,glutamate,immediate early gene,pain,anterior cingulate cortex,spinal cord,serotonin


Department of Physiology,University of Toronto, Faculty of Medicine, Medical Sciences Building,Room &#3342, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada;

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