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Anti-Metastatics: An Overview of Drug Candidates in Current Pipelines

[ Vol. 20 , Issue. 42 ]

Author(s):

Anne Schaap-Nutt, Dane A. Thyssen, David W. Drell and Frank Entschladen   Pages 6522 - 6528 ( 7 )

Abstract:


As the number of novel drugs that have entered the market in oncology has slowed in recent years, there has been a dramatic shift towards new therapeutic approaches. The majority of cancer patients die from metastasis formation, which has prompted the pharmaceutical industry to begin to investigate a new class of agents: anti-metastatics. This review provides an overview of the targets, mechanisms of action, and drug substances currently in the pharma pipeline to inhibit tumor cell migration and metastasis formation.

Keywords:

Metastasis, invasion, cell migration, signal transduction.

Affiliation:

, , , MetaVi Labs Inc, 16238 Ranch Road 620 North, Suite F-347, Austin, Texas 78717, USA.



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