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Peptides-Staple Method Development and Its Application in Cancer Therapy

[ Vol. 21 , Issue. 21 ]

Author(s):

Q.Z. Zhang, Y. Tian, Y.Z. Lao and Z.-G. Li   Pages 2438 - 2452 ( 15 )

Abstract:


α-Helixes are important structural motifs of protein three dimension structures and are largely involved in protein- protein interactions. This review covers the recent advances of the peptide stabilizing methodologies and introduces their applications in cancer research.

Keywords:

Cancer therapy, protein-protein interaction, stapled peptide, α-helix.

Affiliation:

, , , School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, 518055, P. R. China.



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