Milagros Rocha, Susana Rovira-Llopis, Celia Banuls, Lorena Bellod, Rosa Falcon, Raquel Castello, Carlos Morillas, Jose R. Herance, Antonio Hernandez-Mijares and Victor M. Victor Pages 5730 - 5741 ( 12 )
Evidence is mounting of the involvement of mitochondrial dysfunction in insulin resistance, diabetes and associated complications. This review aims to provide an overview of the effects of insulin resistance on mitochondrial function in several tissues. We consider the pathogenesis of insulin resistance from a mitochondrial perspective and contemplate potential beneficial effects of strategies aimed at modulating mitochondrial function in insulin resistance, including insulin and insulin-sensitizing drugs, antioxidants, and selectively targeting antioxidants to mitochondria.
Insulin resistance, mitochondria, oxidative stress, antioxidants.
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