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Colesevelam: A New and Improved Bile Acid Sequestrant?

[ Vol. 19 , Issue. 17 ]


Konstantinos Tziomalos, Asterios Karagiannis, Dimitri P. Mikhailidis and Vasilios G. Athyros   Pages 3115 - 3123 ( 9 )


Treatment with statins represents an essential component both of primary and secondary cardiovascular prevention strategies. However, a proportion of patients cannot reach low-density lipoprotein cholesterol (LDL-C) targets with the highest tolerable dose of a potent statin or is intolerant to statins. Several treatment options are available for these patients. Colesevelam is a relatively new bile acid sequestrant that decreases serum LDL-C levels. Moreover, colesevelam improves glycemic control and seems to be well-tolerated, at least in short-term studies. Therefore, colesevelam seems to be a useful tool for the management of high-risk patients who cannot achieve LDL-C targets with monotherapy with a potent statin.


Colesevelam, statin intolerance, glycemic control, multifactorial intervention, type 2 diabetes mellitus.


, , , AHEPA University Hospital, 1 Stilponos Kyriakidi street, 546 36, Thessaloniki, Greece.

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