Angiotensin II Type 1 and Type 2 Receptor-induced Cell Signaling

Author(s):

Hiroshi Akazawa, Masamichi Yano, Chizuru Yabumoto, Yoko Kudo-Sakamoto and Issei Komuro   Pages 2988 - 2995 ( 8 )

Abstract:

The octapeptide angiotensin II (Ang II) plays a homeostatic role in the regulation of blood pressure and water and electrolyte balance, and also contributes to the progression of cardiovascular remodeling. Ang II activates Ang II type 1 (AT1) receptor and type 2 (AT2) receptor, both of which belong to the seven-transmembrane, G protein-coupled receptor family. Most of the actions of Ang II such as promotion of cellular prolifaration, hypertrophy, and fibrosis are mediated by AT1 receptor. However, in some pathological situations, AT2 receptor shows an increase in tissue expression and functions to antagonize the actions induced by AT1 receptor. Recent studies have advanced our understanding of the molecular mechanisms underlying receptor activation and signal transduction of AT₁ and AT₂ receptor in the cardiovascular system.

Keywords:

Angiotensin II, mechanical stress, receptor dimerization, renin-angiotensin system, signal transduction.

Affiliation:

, , , , Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.

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