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Synthesis of Biologically Active Bridged Diazabicycloheptanes

[ Vol. 19 , Issue. 31 ]

Author(s):

G. Murineddu, B. Asproni, G. Pinna, M.M. Curzu, A. Dore, A. Pau, F. Deligia and G.A. Pinna   Pages 5342 - 5363 ( 22 )

Abstract:


The chemistry underlying how diazabicycloheptanes are assembled is described, subdivided according to chemical structure of two types, the 3,6 diazabicyclo[3.1.1]heptane and the 2,5-diazabicyclo[2.2.1]heptane ring system. Detailed information on myriad of activities of compounds derived from the two scaffolds are reported.

Keywords:

3,6-diazabicyclo[3.1.1]heptanes, 2,5-diazabicyclo[2.2.1]heptanes, synthesis, antibacterial activity, antitumor activity, antiinflammatory activity, analgesic activity, antipsychotic activity, ischemic injuries, obesity

Affiliation:

Department of Chemistry and Pharmacy, University of Sassari, via F. Muroni 23/A, 07100 Sassari, Italy.



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