E. R. Zartler and M. J. Shapiro Pages 3963 - 3972 ( 10 )
Protein NMR as a screening tool in drug discovery has become prominent within the past ten years. Advances in protein manipulation, whether by biological means (labeling) or physical means (NMR), have created a powerful method that is able to observe ligand-target interactions in solution.
NMR,Protein labeling,Chemical Shift Perturbtation,RAMPED-UP
, Department of Pharmaceutical Chemistry, School of Pharmacy, University of Maryland, Baltimore, 20 Penn Street, Baltimore, MD 21201, USA.