Transgenic Mouse Models of Alzheimer Disease: Developing a Better Model as a Tool for Therapeutic Interventions

Author(s):

Masashi Kitazawa, Rodrigo Medeiros and Frank M. LaFerla   Pages 1131 - 1147 ( 17 )

Abstract:

Alzheimer disease (AD) is the leading cause of dementia among elderly. Currently, no effective treatment is available for AD. Analysis of transgenic mouse models of AD has facilitated our understanding of disease mechanisms and provided valuable tools for evaluating potential therapeutic strategies. In this review, we will discuss the strengths and weaknesses of current mouse models of AD and the contribution towards understanding the pathological mechanisms and developing effective therapies.

Keywords:

Alzheimer disease,amyloid-beta,tau,transgenic mouse models,dementia,neurodegeneration,amyloid precursor protein (APP),mild cognitive impairment (MCI),synaptic dysfunction,mutations

Affiliation:

, , School of Natural Sciences, University of California, Merced, 5200 N. Lake Road, Merced, CA 95343.

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