C. Lucke and M. Weiwad Pages 5333 - 5354 ( 22 )
The immunophilins are proteins which are capable of influencing the immune response in combination with an immunosuppressive drug. Their natural function, however, is mainly the cis/trans isomerization of peptidyl-prolyl bonds in other proteins. This review lists all immunophilin structure coordinates currently available in the RCSB protein data bank and highlights the key active-site factors that define their catalytic and immunological action. In addition, an overview of biologically-relevant functions is provided for various immunophilin members.
Calcineurin,cyclophilin,FK506-binding protein,immunophilin,immunosuppression,PPIase domain,peptidyl-prolyl bonds,topology,hydrophobic cyclic,hydrophobic macrolides
, Max Planck Research Unit for Enzymology of Protein Folding, Weinbergweg 22, 06120 Halle (Saale), Germany.