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sFlt-1: a double regulator in angiogenesis-related diseases

Author(s):

Li Liao, Xingtao Zhao, Mengting Zhou, Ying Deng, Yunxia Li* and Cheng Peng  

Abstract:


Background: Vascular endothelial growth factor (VEGF) is a supergene family derived from a platelet growth factor. It plays a pivotal role in regulating angiogenesis and lymphangiogenesis. sFlt-1 is a soluble antagonist of VEGF with an essential effect of maintaining the balance of vascular growth. Recently, sFlt-1 has emerged as a new marker for early diagnosis and disease surveillance of angiogenesis-related diseases. However, few comprehensive reviews focus on the relationship between sFlt-1 and related diseases despite that many results have yielded.

Methods: In this review, we analyzed the relationship between sFlt-1 and angiogenesis-related diseases by searching PubMed, Web of Science, and other databases, and summarized our current understanding of the role of sFlt-1 in angiogenesis-related diseases.

Results: sFlt-1 is associated with pre-eclampsia, perinatal cardiomyopathy, diabetic nephropathy, hypertension, tumor, atherosclerosis, and other diseases. The mechanisms of sFlt-1 that regulate those diseases are mainly associated with the bioavailability of VEGF and vascular endothelial cell integrity.

Conclusion: From the summary article, sFlt-1 is a double regulator in angiogenesis-related diseases; too much or too little may cause different diseases. Therefore, maintaining the stability of sFlt-1 content in the body is essential to control the development of related diseases.

Keywords:

sFlt-1, Preeclampsia, Cardiovascular diseases, Tumor, Retinopathy, Atherosclerosis

Affiliation:

State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu 611137, State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu 611137, State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu 611137, State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu 611137, State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu 611137, State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu 611137



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