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The Regulatory Role of Both MBNL1 and MBNL1-AS1 in Several Common Cancers

Author(s):

Qi Zhang, Yinxin Wu, Jinlan Chen, Yuxuan Cai, Bei Wang, Fangshun Tan, Jie Mou and Chengfu Yuan  

Abstract:


Background: MBNL1, a protein encoded by q25 gene on chromosome 3, belongs to the tissue-specific RNA metabolic regulation family, which controls RNA splicing.[1]MBNL1 formed in the process of development drive large transcriptomic changes in cell differentiation,[2] it serves as a kind of tumor differentiation inhibitory factor.MBNL1 has a close relationship with cancer, comprehensive analysis, [3]found that breast cancer, leukemia, stomach cancer, esophageal adenocarcinoma, glial cell carcinoma and another common tumor in the cut, and cut in Huntington's disease. But MBNL1 plays a promoting role in cervical cancer, is contradictory in colorectal cancer, It promotes colorectal cancer cell proliferation, On the other hand, it inhibits its metastasis, so it is an important physiological marker in many cancers. When we integrated the role of MBNL1 protein in various tumors, we found that its antisense RNA, MBNL1-AS1, had a good inhibitory effect in several colorectal cancer, non-small cell lung cancer, and gastric cancer.

Objective: To elucidate the expression of MBNL1 and MBNL1-AS1 in various tumors, and to search for their physiological markers.

Methods: It was searched by the PUMUB system and summarized its expression in various cancers.

Results: MBNL1 was down-regulated, leukemia, breast cancer, glioblastoma, gastric cancer, overall survival rate, recurrence, metastasis increased. While the metastasis of colon cancer decreased, proliferation was promoted, and the effect of both was promoted for cervical cancer.MBNL1-AS1 was down-regulated, and the overall survival rate, recurrence, and metastasis of lung cancer, colorectal cancer, and bladder cancer increased.

Conclusion: MBNL1 may be an important regulator of cancer, and MBNL1-AS1 is a better tumor suppressor.

Keywords:

MBNL1, MBNL1-AS1, Cancer, Shear, Inhibitory factor, Survival rate, Selective shear

Affiliation:

College of Medical Science, China Three Gorges University, Yichang 443002, College of Medical Science, China Three Gorges University, Yichang 443002, College of Medical Science, China Three Gorges University, Yichang 443002, College of Medical Science, China Three Gorges University, Yichang 443002, College of Medical Science, China Three Gorges University, Yichang 443002, College of Medical Science, China Three Gorges University, Yichang 443002, College of Medical Science, China Three Gorges University, Yichang 443002, College of Medical Science, China Three Gorges University, Yichang 443002



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