Abey Joseph, Arivazhagan Rajendran , Akash Karthikeyan and Baiju G Nair*
Implantable microfluidic devices are milestones in developing devices that can either measure parameters like ocular pressure and blood glucose level or deliver various components for therapeutic needs or behavioral modification. Researchers are currently focusing on the miniaturization of almost all its tools for a better healthcare platform. Implantable microfluidic devices are a combination of various systems including, but not limited to, microfluidic platforms, reservoirs, sensors, and actuators, implanted inside the body of a living entity (in vivo) with the purpose of directly or indirectly helping the entity. It is a multidisciplinary approach with immense potential in the area of the biomedical field. Significant resources are utilizing on for the research and development of these devices for various applications. The induction of an implantable microfluidic device into an animal would enable us to measure the responses without any repeated invasive procedures. Such data would help in the development of a better drug delivery profile. Implantable microfluidic devices with reservoirs deliver specific chemical or biological products to treat situations like cancers and diabetes. They can also deliver fluorophores for specific imaging inside the body. Implantable microfluidic devices help provide a microenvironment for various cell differentiation procedure. These devices know no boundaries, and this article reviews these devices based on their design and applications.
Implantable Microfluidic Devices, Microfluidic platform, Reservoir, Actuators, Sensors, Imaging, Cell differentiation, Drug delivery
School of Biotechnology, National Institute of Technology, Calicut, Kerala, Institute of Advanced Energy, Kyoto University, School of Biotechnology, National Institute of Technology, Calicut, Kerala, School of Biotechnology, National Institute of Technology, Calicut, Kerala