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A Recent Update on Intranasal Delivery of High Molecular Weight Proteins, Peptides, and Hormones

Author(s):

Mayank Sharma, Simran Waghela, Riddhi Mhatre and Gaurav K. Saraogi*  

Abstract:


Proteins and hormones have a wide range of therapeutic uses that have emerged throughout the years. The increase in their clinical application nowadays have outgrown the need to deliver these macromolecules without deterioration and ease of administration, therefore nasal delivery has proven to be the most useful tool. Despite the obstacles, smart polymers, nasal enhancers, nanotechnology-based delivery systems, and computational modelling tools have all been used to increase the residence time and absorption window in the nasal route.In this review, we have highlighted the systemic delivery of macromolecules such as protein and hormones which can also be delivered via nose-to-brain through various transportation pathways. This has proved to be beneficial in the treatment of several neurological disorders like brain tumors, Alzheimer's, Ischemic stroke, etc. Except for the marketed preparation and patents, several other drugs are still under clinical trials. We also like to conclude that many of the newer proteins and hormones are still under developmental stages for which nasal delivery will be a boon in administering these newer molecules as well.

Keywords:

Intranasal Delivery, Macromolecules, Peptides, Hormones, computational modelling, Nose to brain drug delivery

Affiliation:

Dept. of Pharmaceutics, SVKM's NMIMS, School of Pharmacy and Technology Management, NMIMS Shirpur Campus, Maharashtra, Dept. of Pharmaceutics, SVKM's NMIMS, School of Pharmacy and Technology Management, NMIMS Shirpur Campus, Maharashtra, Dept. of Pharmaceutics, SVKM's NMIMS, School of Pharmacy and Technology Management, NMIMS Shirpur Campus, Maharashtra, Sri Aurobindo Institute of Pharmacy, SAIMS Campus, Indore-Ujjain Highway, Near MR-10 crossing, Indore, M.P.



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