Young Nam Kwon and Yong-Jae Kim*
The gut and brain are linked via various bidirectional pathways, communicate with and affect each other. The interaction be-tween the gut-brain axis and the gut microbiota has attracted much attention in the development of hypertension. In this review, we have discussed the gut-brain-microbiota axis and its association with gut dysbiosis in terms of regulation of blood pressure using the autonomic nervous system, immune system, metabolites, hormones, and neurotransmitters. In addition, the treat-ments using microbiota that have been tried to date are briefly summarized. By understanding the mechanism by which gut-brain-microbiota regulates blood pressure, the novel targets for hypertension treatment or a new therapeutic approach us-ing the gut-brain-microbiota could be investigated.
gut-brain-axis, hypertension, microbiota, neurology, immune system, short chain fatty acids, angiotensin II
Department of Neurology, Eunpyeong St. Mary's Hospital, The Catholic University of Korea, Seoul, Department of Neurology, Eunpyeong St. Mary's Hospital, The Catholic University of Korea, Seoul