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Gut-Brain-Microbiota Axis and Hypertension: a literature review

Author(s):

Young Nam Kwon and Yong-Jae Kim*  

Abstract:


The gut and brain are linked via various bidirectional pathways, communicate with and affect each other. The interaction be-tween the gut-brain axis and the gut microbiota has attracted much attention in the development of hypertension. In this review, we have discussed the gut-brain-microbiota axis and its association with gut dysbiosis in terms of regulation of blood pressure using the autonomic nervous system, immune system, metabolites, hormones, and neurotransmitters. In addition, the treat-ments using microbiota that have been tried to date are briefly summarized. By understanding the mechanism by which gut-brain-microbiota regulates blood pressure, the novel targets for hypertension treatment or a new therapeutic approach us-ing the gut-brain-microbiota could be investigated.

Keywords:

gut-brain-axis, hypertension, microbiota, neurology, immune system, short chain fatty acids, angiotensin II

Affiliation:

Department of Neurology, Eunpyeong St. Mary's Hospital, The Catholic University of Korea, Seoul, Department of Neurology, Eunpyeong St. Mary's Hospital, The Catholic University of Korea, Seoul



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