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Recent Advances in Neuromyelitis Optica Spectrum Disorder: Pathogenesis, Mechanisms and Potential Treatments

Author(s):

Yi Du, Kaijun Li, Wei Liu, Ruitong Song, Meifeng Luo, Jianfeng He, Xiaoyu Xu* and Xiaosheng Qu*  

Abstract:


Neuromyelitis optica spectrum disorder (NMOSD) is an acute or subacute demyelinating disease that affects mainly the optic nerve and spinal cord. A major proportion of NMOSD cases have a relationship with autoimmunity to aquaporin 4 (AQP4) found on the central nervous system. NMOSD can occur repeatedly, causing symptoms such as decreased vision and weakness of limbs. The main goal of current therapy is to relieve acute symptoms and prevent recurrence of the disease. Without timely and appropriate treatment, the recurrence and disability rates are high. In the present work, we review recent advances in the diagnosis and treatment of patients with NMOSD, as well as the pathogenesis and mechanisms of AQP4-IgG-seropositive NMOSD.

Keywords:

Devic’s disease, AQP4, autoimmunity, pathogenesis, therapy, NMOSD

Affiliation:

Department of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, Department of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, Department of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, Department of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, Department of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, Department of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, Doheny Eye Institute, Department of Ophthalmology, University of California, Los Angeles, CA 90033, National Engineering Laboratory of Southwest Endangered Medicinal Resources Development, Guangxi Botanical Garden of Medicinal Plants, 530023, Nanning



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