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Liposomes as Versatile Platform for Cancer Theranostics: Therapy, Bio-Imaging, and Toxicological Aspects

Author(s):

Swapnil Mehta, Sanjay Kulkarni, Ajinkya Nitin Nikam, Bharat Singh Padya, Abhijeet Pandey and Srinivas Mutalik*   Pages 1 - 15 ( 15 )

Abstract:


Liposomes are nano-sized formulations having the benefits of site-specificity, biocompatibility, and biodegradability, which make them useful for the therapy and diagnosis of major diseases like cancer. In this review, various synthetic strategies of liposomes and discussed its biomedical application in special concern to cancer. In context to the biomedical application, this article gives a detailed insight on subcellular targeted therapy and several therapeutic modifications like immunotherapy, receptor-based therapy, phototherapy and combination therapy. The review also describes the liposome-based imaging platforms and the toxicity associated with liposomes. Owing to a significant amount of benefits of this carrier system, several products have been approved to be launched in the market and several others have already been marketed for clinical use.

Keywords:

Liposomes, site-specificity, cancer therapy, imaging platform, toxicity, Toxicological Aspects

Affiliation:

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka



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