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Irisin and Vascular Inflammation: Beneficial Effects of a Healthy Lifestyle Beyond Physical Activity

Author(s):

Roberto Restuccia, Fulvio Perani, Giovanni Ficarra, Fabio Trimarchi, Alessandra Bitto* and Debora di Mauro   Pages 1 - 5 ( 5 )

Abstract:


Vascular inflammation is responsible for many cardiovascular diseases and endothelial dysfunction is often the first trigger. Many factors can contribute to alter vascular homeostasis and despite some risk factors cannot be changed, some lifestyle changes might dramatically improve vascular function. In this regards physical activity has been identified as one of the most important interventions that can positively affect endothelial dysfunction. In recent years the discovery of irisin, a novel myokine with pleiotropic effects has caught the attention of many researchers. This review summarizes the most relevant intervention trials,evaluating irisin modifications in subjects with or without cardiovascular risk factors assigned to physical activity programs, to improve cardiovascular risk markers.

Keywords:

Irisin, cardiovascular health, physical activity, Vascular inflammation, endothelial dysfunction, irisin

Affiliation:

Department of Biomedical, Dental, Morphological and Functional Sciences, University of Messina, Messina, Department of Biomedical, Dental, Morphological and Functional Sciences, University of Messina, Messina, Department of Biomedical, Dental, Morphological and Functional Sciences, University of Messina, Messina, Department of Biomedical, Dental, Morphological and Functional Sciences, University of Messina, Messina, Department of Clinical and Experimental Medicine, University of Messina, Messina, Department of Biomedical, Dental, Morphological and Functional Sciences, University of Messina, Messina



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