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Cardio-protective Effects of Glucagon-like Peptide-1 Receptor Agonists: An Overview of Systematic Reviews and Publication Overlap

Author(s):

Stefanos Zafeiropoulos, Areti Pagiantza, Ioannis Doundoulakis, Nikolaos Stalikas, Ioannis Farmakis, Athanasios Samaras, Christina Antza and George Giannakoulas*   Pages 1 - 12 ( 12 )

Abstract:


Background: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as a new antihyperglycemic class with the demonstrated advantage of reducing major adverse cardiovascular events (MACE) among individuals with type 2 diabetes (T2DM) and atherosclerotic cardiovascular disease or high cardiovascular risk.

Objective: Τo summarize the evidence of systematic reviews (SRs) that assess MACE (cardiovascular mortality, nonfatal myocardial infarction and stroke) and hospitalizations for heart failure in GLP-1RAs-treated patients and to evaluate possible overlap in pertinent SRs.

Methods: We performed a comprehensive search via MEDLINE, Cochrane Library, and PROSPERO databases up to February 23, 2020 for SRs examining cardiovascular outcomes of GLP-1RAs in T2DM patients. Three independent authors extracted data and assessed the methodological quality of the included SRs using the ROBIS tool.

Results: We found 37 SRs – published between 2009 and 2020 in English – of which 35 collected data only from randomized clinical trials while two from observational studies as well. The methodological quality of the 37 SRs ranged from low to high while only 3 have evaluated the overall quality of evidence outcome using the Grading of Recommendations Assessments, Development and Evaluation (GRADE) approach. All the included SRs showed cardiovascular safety of GLP-1RAs while the latest ones demonstrated reduction in composite MACE endpoint as well as its every individual component and heart failure hospitalizations.

Conclusion: In the first overview of SRs about cardiovascular outcomes of GLP-1RAs, they proved favorable effects on reducing cardiovascular events in T2DM patients. There are, however, many overlapping reviews based on relatively few cardiovascular outcomes trials.

Keywords:

Glucagon-Like Peptide-1 Receptor Agonists, Diabetes Mellitus, Cardiovascular Outcomes, type 2 diabetes (T2DM), antihyperglycemic class, Systematic Reviews

Affiliation:

1 st Department of Cardiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, 1 st Department of Cardiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, 1 st Department of Cardiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, 1 st Department of Cardiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, 1 st Department of Cardiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, 1 st Department of Cardiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, 3 rd Department of Internal Medicine, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, 1 st Department of Cardiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki



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