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The State of the Problem of Achieving Extremely Low LDL Levels

Author(s):

Victoria Korneva*, Tatiana Kuznetsova and Ulrich Julius   Pages 1 - 17 ( 17 )

Abstract:


Patients who have achieved very low low-density lipoprotein cholesterol (LDL-C) levels in clinical trials have the lowest cardio-vascular risk. The current clinical guidelines set such concentration for LDL-C as < 1.4 mmol/L. However, the question of minimum permissible target values of the lipids remains unresolved. A number of experimental and clinical studies showed some unfavorable consequences of low LDL-C levels, at the same time, the modern arsenal of lipid lowering drugs allows reducing LDL-C levels to extremely low values.

Keywords:

low-density lipoprotein cholesterol (LDL-C), PCSK9 inhibitors, statins, diabetes mellitus, immune system, malignant neoplasms, brain function

Affiliation:

Petrozavodsk State University, Faculty Therapy Department, 185000 Lenin Ave., 33, Petrozavodsk,, Petrozavodsk State University, Faculty Therapy Department, 185000 Lenin Ave., 33, Petrozavodsk,, Lipidology and Lipoprotein Apheresis Center, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universt├Ąt Dresden, Fetscherstr. 74, 01307 Dresden



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