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Article Details


Peripheral Artery Disease in Diabetes Mellitus: Focus on Novel Treatment Options

[ Vol. 26 , Issue. 46 ]

Author(s):

Andrea Demarchi, Alberto Somaschini, Stefano Cornara and Emmanuel Androulakis*   Pages 5953 - 5968 ( 16 )

Abstract:


Diabetes mellitus (DM) and peripheral artery disease (PAD) are two clinical entities closely associated. They share many pathophysiological pathways such as inflammation, endothelial dysfunction, oxidative stress and pro-coagulative unbalance. Emerging data focusing on agents targeting these pathways may be promising. Moreover, due to the increased cardiovascular risk, there is a growing interest in cardiovascular and “pleiotropic” effects of novel glucose lowering drugs. This review summarizes the main clinical features of PAD in patients, the diagnostic process and current medical/interventional approaches, ranging from “classical treatment” to novel agents.

Keywords:

Diabetes mellitus, peripheral artery disease, novel treatments, pro-coagulative unbalance, pleiotropic, endothelial dysfunction.

Affiliation:

Cardiocentro Ticino, Lugano, Adult Intensive Care Unit, Royal Brompton & Harefield NHS Foundation Trust, London, Department of Cardiology, San Paolo Hospital, Savona, Adult Intensive Care Unit, Royal Brompton & Harefield NHS Foundation Trust, London



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