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GnRH in the treatment of Hypogonadotropic Hypogonadism

Author(s):

Carlo Bettocchi*, Marco Rinaldi and Francesco Sebastiani   Pages 1 - 3 ( 3 )

Abstract:


Gonadotropin Releasing Hormone (GnRH) is at the centre of the scientific debate for the treatment of hypogonadotropic hypogonadism. Sexual maturation and reproductive function depend on the pulsatile secretion of GnRH are mainly congenital and may or may not be associated with other genetic anomalies or syndromes. Clinical manifestations include a wide range of metabolic, endocrine and psychologic dysfunctions. The following manuscript focuses on the effects of GnRH therapy on fertility and cognitive abilities, aiming to investigate the current level of evidence for this treatment regimen. Current literature has been reviewed and synthesized with the aim of highlighting the key messages on these two aspects.

Keywords:

GnRH; Hypogonadotropic hypogonadism, hypogonadism treatment, fertility, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome, combined pituitary hormone deficiency, cognition.

Affiliation:

Department of Emergency and Organ Transplantation - Urology, Andrology and Kidney Transplantation Unit - University of Bari, Department of Emergency and Organ Transplantation - Urology, Andrology and Kidney Transplantation Unit - University of Bari, Department of Emergency and Organ Transplantation - Urology, Andrology and Kidney Transplantation Unit - University of Bari



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