Monireh Torabi-Rahvar and Nima Rezaei* Pages 1 - 4 ( 4 )
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may lead to severe disease in some cases, leading to acute respiratory distress syndrome, multi-organ failure, and death. This severe phenotype seems to be associated with a cytokine storm and immune dysregulation. Increased pro-inflammatory cytokines and CD14+CD16+ inflammatory monocytes, lymphopenia, and decreased levels of regulatory T cells are some of the immunological features that are seen in patients with SARS-CoV-2. As the outcome of SARS-CoV-2 is influenced by both viral virulence and dysregulated inflammatory response, a combination therapy approach using antiviral drugs plus anti-inflammatory treatments, such as corticosteroids, monoclonal antibodies against the IL-6 and IL-1β pathways, and JAK inhibitors are under clinical trials.
Severe acute respiratory syndrome coronavirus 2, Cytokine storm, Proinflammatory cytokines, Monoclonal antibodies
Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran