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Storm at the Time of Corona: A Glimpse at the Current Understanding and Therapeutic Opportunities of the SARS-CoV-2 Cytokine Storm

Author(s):

Monireh Torabi-Rahvar and Nima Rezaei*   Pages 1 - 4 ( 4 )

Abstract:


Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may lead to severe disease in some cases, leading to acute respiratory distress syndrome, multi-organ failure, and death. This severe phenotype seems to be associated with a cytokine storm and immune dysregulation. Increased pro-inflammatory cytokines and CD14+CD16+ inflammatory monocytes, lymphopenia, and decreased levels of regulatory T cells are some of the immunological features that are seen in patients with SARS-CoV-2. As the outcome of SARS-CoV-2 is influenced by both viral virulence and dysregulated inflammatory response, a combination therapy approach using antiviral drugs plus anti-inflammatory treatments, such as corticosteroids, monoclonal antibodies against the IL-6 and IL-1β pathways, and JAK inhibitors are under clinical trials.

Keywords:

Severe acute respiratory syndrome coronavirus 2, Cytokine storm, Proinflammatory cytokines, Monoclonal antibodies

Affiliation:

Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran



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