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Biological and Pharmacological Effects of Gamma-oryzanol: An Updated Review of the Molecular Mechanisms

Author(s):

Elham Ramazani, Maryam Akaberi, Seyed Ahmad Emami and Zahra Tayarani-Najaran*   Pages 1 - 18 ( 18 )

Abstract:


Background: Gamma-oryzanol (γ-oryzanol) is one of the rice bran oil (RBO) compounds, known as a principal food source throughout the world. In recent numerous experimental studies, γ-oryzanol has been revealed to have several useful pharmacological properties such as antioxidant, anti-inflammatory, anticancer, anti-diabetic, ameliorating menopausal unpleasant symptoms, cholesterol-lowering, plasma lipid pattern improving, etc.

Methods: In this study we reviewed the scientific literature published up until 2020, which have evaluated the biological and pharmacological activity of gamma-oryzanol. This review summarizes the published data found in PubMed, Science Direct and Scopus.

Results & Conclusion: The present review attempts to summarize the most related articles about the pharmacologic and therapeutic potential from recent studies on γ-oryzanol to gain insights for design further studies to achieve new evidence which confirm observed effects.

Keywords:

γ-oryzanol, Rice bran oil, antioxidant, cholesterol-lowering, anti-diabetic

Affiliation:

Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Department of Pharmacognosy, School of pharmacy, Mashhad University of Medical Sciences, Mashhad, Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad



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