Mimansa Kandhwal, Tapan Behl*, Arun Kumar and Sandeep Arora Pages 1 - 16 ( 16 )
Nitric oxide (NO) is a promising pharmaceutical component that has vasodilator, antibacterial and wound healing activity. Chronic ulcers are non-healing disorders that are generally associated with distortion of lower limbs. Among the severe consequence’s derivative of these diseases, are the problems of chronic wound progression. NO which is categorized as smallest gaseous neurotransmitter has beneficial effects in different phases of chronic inflammation. Defensive mechanism of NO is found useful in several severe conditions such as gestational healing, gastrointestinal healing and diabetic healing. The current review presents up to date collection of literature about role of NO in chronic ulcers due to the prevalence of diabetes, DPN, and diabetic foot ulcers, and because of the lack of available effective treatments to directly address the pathology contributing to these conditions, novel treatments are being sought. This review also collects the information about deficiency of NO synthase in diabetic patients leads to a lack of vascularization of the peripheral nerves, which causes diabetic neuropathy; and this could be treated with vasodilators such as nitric oxide. Apart from pharmacological mechanism of NO, the article also reviewed and analyzed to elucidate the potential of a transdermal delivery of NO for the treatment of chronic ulcers.
Nitric oxide, Nanoparticles, Antimicrobial, Biopolymers, Wound healing
Chitkara College of Pharmacy, Chitkara University, Punjab, Chitkara College of Pharmacy, Chitkara University, Punjab, Chitkara College of Pharmacy, Chitkara University, Punjab, Chitkara College of Pharmacy, Chitkara University, Punjab