Phuong H.L. Tran, Beom-Jin Lee and Thao T.D. Tran* Pages 1 - 9 ( 9 )
Solid dispersions offer many advantages for oral drug delivery of poorly water-soluble drugs over other systems, including an increase in drug solubility and drug dissolution. The improvement of drug absorption and higher bioavailability of active pharmaceutical ingredients in the gastrointestinal tract have been reported in various studies. In certain circumstances, a rapid pharmacological effect is required for patients. Fast-dissolving solid dispersions provide an ideal formulation in such cases. This report will provide an overview of current studies on fast-dissolving solid dispersions, including not only solid dispersion powders with fast dissolution rates but also specific does forms for the controlled release of poorly water-soluble drugs. Specifically, the applications of fast-dissolving solid dispersions will be described in every specific case. Moreover, pharmaceutical approaches and the utilization of polymers will be summarized. The classification and analysis of fast-dissolving solid dispersions could provide insight into strategies and potential applications in future drug delivery developments.
solid dispersion, fast dissolving, controlled release, poorly water-soluble drugs, oral delivery.
Deakin University, Geelong Australia, School of Medicine, College of Pharmacy, Ajou University, Suwon, Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City