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Polymeric Nanoparticles of Aromatase Inhibitors: A Comprehensive Review

[ Vol. 27 , Issue. 6 ]

Author(s):

Keerti Mishra, Pooja Ratre, Suresh Thareja and Akhlesh K. Jain*   Pages 855 - 865 ( 11 )

Abstract:


Being the second most frequent cancer, breast cancer is emerging worldwide with an alarming rate, specifically in post-menopausal women. Targeted drug delivery has been in the focus for the successful treatment of breast cancer by enhancing the drug delivery efficiency and reducing the systemic toxicity of drugs. Also, it eliminates the drawbacks associated with conventional chemotherapy, including neuropathy, memory loss, cardiotoxicity and low RBCs count. This review elaborates the polymeric nanoparticles based formulation approaches for selective and sustained delivery for effective cure of breast cancer. However, breast cancer, a life-threatening disease, is mostly caused because of estrogen, thus aromatase inhibitors and estrogen synthesis inhibitors could prevent chances of breast cancer. The disease is associated with drug resistance and some side effects, which could be easily eliminated by using novel therapeutic approaches. Aromatase inhibitors, when entrapped in nanoparticles, have shown sustained drug release, advocating themselves to be beneficial for the treatment of breast cancer.

Keywords:

Breast cancer, estrogen, aromatase, aromatase inhibitors, nano drug delivery, nanoparticles.

Affiliation:

School of Pharmaceutical Sciences, Guru Ghasidas Central University, Bilaspur- 495 009 (C.G.), School of Pharmaceutical Sciences, Guru Ghasidas Central University, Bilaspur- 495 009 (C.G.), Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda-151 001 (Punjab), School of Pharmaceutical Sciences, Guru Ghasidas Central University, Bilaspur- 495 009 (C.G.)



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