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A Glassy Carbon Electrode for the Determination of Linagliptin, an Antidiabetic Drug in Pure Form, Tablets and Some Biological Fluids by Adsorptive Stripping Voltammetry

Author(s):

Ahmed A Gahlan, Ahmed M Haredy*, Sayed M Derayea, Mahmoud A Omar and Gamal A Saleh   Pages 1 - 10 ( 10 )

Abstract:


Aim: The present work provides a fast, simple, accurate, and inexpensive analytical method for the determination of Linagliptin (anti-diabetic drug).

Methods: Using a square wave adsorptive anodic stripping voltammetric technique (SWAASV) and glassy carbon electrode (GCE) as a working electrode. The experimental and instrumental parameters were studied and discussed to ensure the validity of the method.

Results: The method has a very good linearity (R2 = 0.9984), wide concentration range (0.189 - 2.268) µg mL -1 ), low detection limit 0.052 µg mL -1 and low quantitation limit 0.172 µg mL -1 .

Conclusion: Linagliptin was determined successfully in pharmaceutical form, spiked urine and plasma with 99.67, 91.96, and 92.78 % recovery respectively by using the proposed method, and the results obtained were compared with other reported methods.

Keywords:

Linagliptin, glassy carbon electrode, Square wave voltammetry, Pharmaceutical, pure form, and biological fluids.

Affiliation:

Chemistry Department, Faculty of Science, Al-Azhar University, Assiut Branch, Assiut, Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut



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