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Mucoadhesive Formulation Designs for Oral Controlled Drug Release at the Colon

[ Vol. 27 , Issue. 4 ]

Author(s):

Phuong H.L. Tran and Thao T.D. Tran*   Pages 540 - 547 ( 8 )

Abstract:


Mucoadhesive formulations have been demonstrated to result in efficient drug delivery systems with advantages over existing systems such as increased local retention and sustained drug release via adhesiveness to mucosal tissues. The controlled release of colon-targeted, orally administered drugs has recently attracted a number of studies investigating mucoadhesive systems. Consequently, substantial designs, from mucoadhesive cores to shells of particles, have been studied with promising applications. This review will provide an overview of specific strategies for developing mucoadhesive systems for colon-targeted oral delivery with controlled drug release, including mucoadhesive matrices, cross-linked mucoadhesive microparticles, coatings and mucoadhesive nanoparticles. The understanding of the basic principle of these designs and advanced formulations throughout will lead to the development of products with efficient drug delivery at the colon for therapies for different diseases.

Keywords:

Colonic delivery, controlled release, mucoadhesive drug delivery system, mucoadhesive nanoparticles, mucoadhesive matrices, mucoadhesive formulations.

Affiliation:

Deakin University, School of Medicine, IMPACT, Institute for Innovation in Physical and Mental Health and Clinical Translation, Geelong, Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City



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