R. Schobert, S. Knauer, S. Seibt and B. Biersack Pages 790 - 807 ( 18 )
An overview of anticancer active spirocyclopropanes of the illudin class is provided. After a short introduction on the history and general chemistry of illudins M and S, new discoveries concerning their mode of action and metabolism are reported as well as new synthetic endeavors towards derivatives with improved selectivity for and efficacy against cancer cells. In addition, common and recently tapped biological sources and isolation procedures for known and new illudins are discussed. Pertinent literature is covered up to 2010.
Alkylating agents,illudins,irofulven,anticancer drugs,fungal agents,spirocyclopropanes,metabolism,bionucleophiles,cyclophosphamide,basidiomycetes,lantern mushroom,mitomycins
, , , Organic Chemistry Laboratory, University of Bayreuth, Universitaetsstrasse 30, D-95440 Bayreuth, Germany.