Submit Manuscript  

Article Details


Targeting Cancer using Curcumin Encapsulated Vesicular Drug Delivery Systems

Author(s):

Joel Hardwick, Jack Taylor, Meenu Mehta, Saurabh Satija, Keshav R. Paudel, Philip M. Hansbro, Dinesh K. Chellappan, Mary Bebawy and Kamal Dua*   Pages 1 - 13 ( 13 )

Abstract:


Curcumin is a major curcuminoid present in turmeric. The compound is attributed with various therapeutic properties, which include, anti-oxidant, anti-inflammatory, anti-bacterial, anti-malarial, and neuroprotection. Due to its therapeutic potential, curcumin has been employed for centuries in treating different ailments. Curcumin has been investigated lately as a novel therapeutic agent in the treatment of cancer. However, the mechanisms by which curcumin exerts its cytotoxic effects on malignant cells are still not fully understood. One of the main limiting factors in the clinical use of curcumin is its poor bioavailability and rapid elimination. Advancements in drug delivery systems such as, nanoparticle based vesicular drug delivery platforms have improved several parameters, namely, drug bioavailability, solubility, stability, and controlled release properties. The use of curcumin-encapsulated niosomes to improve the physical and pharmacokinetic properties of curcumin is one such approach. This review provides an up-to-date summary on nanoparticle based vesicular drug carriers and their therapeutic applications. Specifically, we focus on niosomes as novel drug delivery formulations and their potential in improving the delivery of challenging small molecules, including curcumin. Overall, the applications of such carriers will provide a new direction for novel pharmaceutical drug delivery, as well as, biotechnology, nutraceutical, and functional food industries.

Keywords:

Cancer, curcumin, exosomes, liposomes, nanoformulations, niosomes, pro-niosomes, vesicular.

Affiliation:

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Centre for Inflammation, Centenary Institute, Sydney, NSW, 2050, Centre for Inflammation, Centenary Institute, Sydney, NSW, 2050, Department of Life Sciences, School of Pharmacy, International Medical University, 57000 Bukit Jalil, Kuala Lumpur, Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007



Read Full-Text article