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Folic acid conjugated nanocarriers for efficient targetability and promising anticancer efficacy for treatment of breast cancer: A review of recent updates.

Author(s):

Hira Choudhury, Manisha Pandey*, Lee Pei Wen, Ling Kah Cien, Ho Xin, Alvina Ng Jia Yee, Ng Joo Lee, Bapi Gorain, Mohd Cairul Iqbal Mohd Amin and Mallikarjuna Rao Pichika   Pages 1 - 19 ( 19 )

Abstract:


Background: Breast cancer (BC) is one of the most common and prevalent cancer types among women. It is caused mainly due to mutations in receptors of estrogen or progesterone. There are several conventional treatment strategies available which include chemotherapy, radiation therapy, and partial or entire mastectomy. These are being most frequently used by most of the healthcare professionals for the treatment of BC. These commonly traditional forms of available treatment therapy, however, were often associated with multiple adverse effects, thus reducing patient compliance.

Objective: This review focuses on therapeutic strategies driven by nanotechnology that are recognized as a frontline therapy to enhance therapeutic effectiveness and the unintended side-effects associated with incorporated anticancer drugs in the treatment of breast cancer.

Results: Although there are several nanocarriers available, the folic acid conjugated nanocarriers have shown remarkable efficiency of specific targeting due to their promising specificity for overexpressed folate receptors on the surface of breast cancer cells. The target-specificity of folate-conjugated nanocarriers results in a substantial improvement in medication internalization in breast cancer cells and further decreases accumulation into the non-target organs. Despite having an excellent therapeutic anticancer efficacy, folate-conjugated nanocarriers have also evidenced of having noninvasive imaging for regular monitoring of targeted drug delivery system and their responses to an anticancer therapy.

Conclusions: In addition, the objective of this review is to demonstrate the potential of folate-conjugated nanotherapeutics for the treatment of breast cancer along with the significant challenges to anticancer therapy, and the prospective insights on its clinical importance and effectiveness of folate conjugate nanocarriers.

Keywords:

Folic acid, Folic acid conjugation, Breast cancer, Nanotechnology, Targeted drug delivery, Theranostic approach, Chemotherapies.

Affiliation:

Department of Pharmaceutical Technology, School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Department of Pharmaceutical Technology, School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Undergraduate, School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Undergraduate, School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Undergraduate, School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Undergraduate, School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Undergraduate, School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, School of Pharmacy, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya, Selangor 47500, Centre for Drug Delivery Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur



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