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Targeting Toll like Receptors in Cancer: Role of TLR Natural and Synthetic Modulators

Author(s):

Arunaksharan Narayanankutty, Aswathi Sasidharan and Joice Tom Job*   Pages 1 - 13 ( 13 )

Abstract:


Background: Toll like receptors (TLRs) are a group of transmembrane receptors belonging to the broad class pattern recognition receptors (PRR), involved in the recognition of Pathogen Associated Molecular Patterns (PAMPs) and thereby inducing an immune response. Apart from these exogenous PAMPs, numerous endogenous PAMPs are also ligands for various TLRs thereby activating the TLR dependent immune response, subsequently leading to the onset of an inflammatory response. Prolonged activation of TLR by these endogenous PAMPs leads to chronic inflammatory insults to the body and which in turn alters the proliferative patterns of the cells, which ultimately leads to the development of cancer.

Objectives: The present review aims to provide a detailed outline of the differential roles of various TLRs in cancer and the possible use of them as a therapeutic target.

Methods: Data were collected from PubMed/Sciencedirect/Web of Science database and sorted; the latest literature on TLRs was incorporated in the review.

Results: Among the different TLRs, few are reported to be anti-neoplastic, which controls the cell growth and multiplication in response to the endogenous signals. On the contrary, numerous studies have reported the pro-carcinogenic potentials of TLRs. Hence, TLRs has emerged as a potential target for the prevention and treatment of various types of cancers. Several molecules such as monoclonal antibodies, small molecule inhibitors and natural products have shown promising anticancer potential by effectively modulating the TLR signalling.

Conclusion: Toll like receptors play vital roles in the process of carcinogenesis, hence TLR targeting is a promising approach for cancer prevention.

Keywords:

Toll like receptor, Cancer, TLR modulators, Metastasis, Natural products

Affiliation:

Department of Zoology, Malabar Christian College (Affiliated to the University of Calicut), Calicut, Kerala, National Centre for Biological Science, Bengaluru, Department of Zoology, St. Joseph’s College (Autonomous), Devagiri, Calicut, Kerala



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