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Experimental and Clinical Evidence of Endothelial Dysfunction in Inflammatory Bowel Disease

[ Vol. 26 , Issue. 30 ]

Author(s):

Mariana Ferreira-Duarte, Joana Beatriz Sousa, Carmen Diniz, Teresa Sousa, Margarida Duarte-Araújo and Manuela Morato*   Pages 3733 - 3747 ( 15 )

Abstract:


The endothelium has a crucial role in proper hemodynamics. Inflammatory bowel disease (IBD) is mainly a chronic inflammatory condition of the gastrointestinal tract. However, considerable evidence points to high cardiovascular risk in patients with IBD. This review positions the basic mechanisms of endothelial dysfunction in the IBD setting (both clinical and experimental). Furthermore, we review the main effects of drugs used to treat IBD in endothelial (dys)function. Moreover, we leave challenging points for enlarging the therapeutic arsenal for IBD with new or repurposed drugs that target endothelial dysfunction besides inflammation.

Keywords:

Inflammatory Bowel Disease, endothelium dysfunction, experimental and clinical studies, hemodynamics, cardiovascular, IBD.

Affiliation:

LAQV@REQUIMTE, University of Porto, Porto, LAQV@REQUIMTE, University of Porto, Porto, LAQV@REQUIMTE, University of Porto, Porto, Department of Biomedicine, Unit of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, LAQV@REQUIMTE, University of Porto, Porto, LAQV@REQUIMTE, University of Porto, Porto



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