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Colloidal Nanocarriers as Versatile Targeted Delivery Systems for Cervical Cancer

Author(s):

Abimanyu Sugumaran* and Vishali Mathialagan   Pages 1 - 14 ( 14 )

Abstract:


Background: The second most common malignant cancer in uterine is cervical cancer, which presents worldwide with a rising death rate, predominantly in developing countries. Even though the different class of anticancer agents used to treat cervical carcinoma, which results in many severe untoward effects, toxicity and multidrug resistance (MDR) with higher chances of recurrence and spread beyond the pelvic. Moreover, the resulting clinical outcome remains very poor even after surgical procedures and treatment with conventional chemotherapy. This significant disadvantage of non-specificity wipes out both cancerous and normal tissues. The colloidal nanodispersions have been focusing on sitespecific delivery to cervical cancer with great attention and much advancement.

Methods: This review aims to demonstrate the problems of current treatment and explore the potential of colloidal nanocarriers towards the selective delivery of anticancer drugs to cervical cancer using various available literature.

Results: In this study, we surveyed the role and potential of different colloidal nanocarriers in cervical cancer, such as nanoemulsion, nanodispersions, polymeric nanoparticles, and metallic nanoparticles and photothermal and photodynamic therapy. We found that the great advancement in colloidal nanocarrier based cervical cancer treatment.

Conclusion: In conclusion, cervical cancer targeted treatment with the colloidal nanocarriers would hopefully result in minimal toxic side effects, dosage frequency, and lower MDR incidence and enhance the patient survival rates. The future direction of the study could be more focused towards the regulatory barrier of nanocarriers based clinical outcomes for cervical cancer targeting with cost-effective analysis.

Keywords:

Colloidal Nanocarrier, Cervical Cancer Targeting, Nanoparticles, Drug Delivery System, Polymeric Nanoparticles, Nanoencapsulation.

Affiliation:

Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur 603203, Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur 603203



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