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Sumoylation as an Emerging Target in Therapeutics against Cancer

[ Vol. 26 , Issue. 37 ]

Author(s):

Sitong Liu, Lichun Wang, Dongjun Jiang, Wei Wei, Mushyeda Fatima Nasir, Muhammad Saad Khan, Qudsia Yousafi, Xintong Liu, Xueqi Fu*, Xiaomeng Li* and Jiang Li*   Pages 4765 - 4776 ( 12 )

Abstract:


Sumoylation is the posttranslational modification gaining significant research interest, recently. Sumoylation is involved in various crucial functions of the cell, such as the regulation of cell cycle, DNA damage repair, apoptosis etc. Oncology is advancing in radiotherapy, targeted chemotherapy, various forms of immunotherapy and targeted gene therapy. Research works are being conducted to prove its connotation with a variety of cancers and inhibitors are being developed to obstruct the fatal effect caused by misbalance of the SUMOcatalytic cycle. It has been shown that the up-regulation of certain enzymes of Sumoylation correlates with cancer incidence in most of the cases. But, in some cases, down-regulation is also associated with cancer invasion, such as under-expression of UBC9 in initial stage breast cancer. This can aid in future study, treatment and diagnosis of a variety of cancers, including breast cancer, prostate cancer, lung adenocarcinoma, melanoma, multiple myeloma etc. Various mechanistic assays are being developed and used to identify potential inhibitors against the dysregulated proteins of Sumoylation. This review summarizes the normal roles of the enzymes involved in the SUMO catalytic cycle, their misbalanced regulation leading to tumorigenesis and nearly all the potent inhibitors identified till now.

Keywords:

Post-translational modifications, ubiquitination, Sumoylation, Sentrin-specific proteases, Sumo Activating Enzyme, RWDdomain- containing Sumoylation Enhancer.

Affiliation:

The Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, The Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, The Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, The Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, Department of Biosciences, Faculty of Sciences, COMSATS University Islamabad, Sahiwal, Department of Biosciences, Faculty of Sciences, COMSATS University Islamabad, Sahiwal, Department of Biosciences, Faculty of Sciences, COMSATS University Islamabad, Sahiwal, Dental Hospital, Jilin University, Changchun 130021, College of Life Sciences, Jilin University, Changchun, 130012, The Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, Stomatological Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510150



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