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Using Alendronic Acid Coupled Fluorescently Labelled SM Liposomes as a Vehicle for Bone Targeting

Author(s):

Oula Peñate Medina*, Tuula Peñate Medina, Jana Humbert, Bao Qi, Wolfgang Baum, Olga Will, Timo Damm and Claus Glüer   Pages 1 - 7 ( 7 )

Abstract:


Background: We have recently developed a liposomal nanoparticle system that can be used for drug delivery and simultaneously be monitored by optical or photoacoustic imaging devices. Here we tested the efficacy of alendronate as a homing molecule in SM-liposomes for bone targeting.

Methods: Alendronate was immobilized covalently on the liposomal surface and the fluorescent dye indocyanine green was used as a payload in the liposomes. The indocyanine green delivery was analyzed by 3D optical tomography, optical fluorescence scanner, photoacoustic imaging, and by exvivo biodistribution studies.

Results: The results show that the alendronate coupled to the liposomal surface increases Sphingomyelin containing liposome targeting up to several fold.

Conclusion: The alendronate targeted liposomes open possibilities for an application in active bone targeting.

Keywords:

alendronic acid, liposomes, multimodal imaging, ICG, sphingomyelin

Affiliation:

Section Biomedical Imaging, Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein [UKSH], Kiel University, Kiel, Section Biomedical Imaging, Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein [UKSH], Kiel University, Kiel, Section Biomedical Imaging, Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein [UKSH], Kiel University, Kiel, Section Biomedical Imaging, Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein [UKSH], Kiel University, Kiel, Universitätsklinikum Erlangen, Medizinische Klinik 3 Institut für Klinische Immunologie, Glückstrasse 4A 91054 Erlangen, Section Biomedical Imaging, Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein [UKSH], Kiel University, Kiel, Section Biomedical Imaging, Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein [UKSH], Kiel University, Kiel, Section Biomedical Imaging, Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein [UKSH], Kiel University, Kiel



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