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Sericin: A Versatile Protein Biopolymer with Therapeutic Significance

Author(s):

Rasika Suryawanshi, Jovita Kanoujia, Poonam Parashar and Shubhini A. Saraf*   Pages 1 - 16 ( 16 )

Abstract:


Sericin is a unique proteinaceous biopolymer obtained from cocoons of Bombyx Mori. It has become very popular since it is bestowed with numerous health benefits. Sericin is composed of 18 types of amino acids, out of which 8 amino acids play a significant role in human metabolic pathways. Sericin is easily amenable to make into novel dosage forms and also has been conferred with numerous therapeutic activities such as wound healing, antihypertensive, neuro-protective, antitumor, anti-diabetic, anti-wrinkle, anti-ageing and antioxidant amongst various others. This review summarizes the current status of sericin, as a therapeutic moiety with a focus on active constituents as well as their proposed mechanism in the treatment of various chronic diseases. It also summarizes previous and current invitro, in-vivo, cell lines studies and clinical trials based pieces of evidence corroborating the therapeutic activities of sericin.

Keywords:

Sericin, silk nanoparticles, protein nanoparticles, Bombyx Mori, novel drug delivery

Affiliation:

Clinical Pharmacology and Pharmacometrics, Bristol Mayers Squibb, Lawrencevile, New Jersey, Amity Institute of Pharmacy, Amity University of Madhya Pradesh, Maharajapura, Gwalior, Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (A Central University), VidyaVihar, Raebareli Road, Lucknow, U.P, Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (A Central University), VidyaVihar, Raebareli Road, Lucknow, U.P



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