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Possible Involvement of N-methyl-D-aspartate Receptor (NMDA-R) in the Antidepressant- Like Effect of Trigonelline in Male Mice

Author(s):

Maryam Anjomshoa, Shakiba Nasiri Boroujeni, Esmaeel Bagheri, Zahra Lorigooini and Hossein Amini-Khoei*   Pages 1 - 5 ( 5 )

Abstract:


Background and Aim: Depression is a mood disorder with high global prevalence. Depression is associated with a reduction in the hippocampal volume and change in its neurotransmitters function. Trigonelline is an alkaloid with neuroprotective activity. The aim of this study was to investigate the possible role of N-methyl-D-aspartate (NMDA) receptor in the antidepressantlike effect of trigonelline considering histopathological modifications of the hippocampus.

Methods: 60 Naval Medical Research Institute (NMRI) male mice were divided into 6 groups including group 1 (normal saline), groups 2, 3 and 4 (trigonelline at doses of 10, 50 and 100 mg/kg), group 5 (effective dose of trigonelline plus NMDA agonist), group 6 (sub-effective dose of trigonelline plus NMDA antagonist). Forced swimming test (FST) was used to assess depressive-like behavior. Hippocampi were separated under deep anesthesia and used for histopathological evaluation as well as NMDA receptor gene expression assessment.

Results: Trigonelline at doses of 10, 50 and 100 significantly reduced the immobility time in the FST in comparison to the control group. The administration of the sub-effective dose of trigonelline plus ketamine (a NMDA receptor antagonist) potentiated the effect of the subeffective dose of trigonelline. In addition, co-treatment of effective dose of trigonelline with NMDA mitigated the antidepressant-like effect of trigonelline. Trigonelline at doses of 50 and 100 mg/kg significantly increased the diameter of the CA1 area of the hippocampus.

Conclusion: Trigonelline showed an antidepressant-like effect in mice probably via attenuation of NMDA receptor activity and increase in the CA1 region of the hippocampus.

Keywords:

Depression, NMDA receptor, hippocampus, trigonelline, miceDepression, NMDA receptor, hippocampus, trigonelline, mice

Affiliation:

Medical plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Medical plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Medical plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Medical plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Medical plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord



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