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Applications of Nanocarriers as Drug Delivery Vehicles for Active Phytoconstituents

[ Vol. 26 , Issue. 36 ]

Author(s):

Phui Qi Ng, Laura Soon Cheau Ling, Jestin Chellian, Thiagarajan Madheswaran, Jithendra Panneerselvam, Anil Philip Kunnath, Gaurav Gupta, Saurabh Satija, Meenu Mehta, Philip Michael Hansbro, Trudi Collet, Kamal Dua* and Dinesh Kumar Chellappan*   Pages 4580 - 4590 ( 11 )

Abstract:


Many plant-based bioactive compounds have been serving as the origin of drugs since long ago and many of them have been proven to have medicinal value against various chronic diseases, including, cancer, arthritis, hepatic diseases, type-2 diabetes and cardiovascular diseases. However, their clinical applications have been limited due to their poor water solubility, stability, low bioavailability and extensive transformation due to the first-pass metabolism. The applications of nanocarriers have been proven to be able to improve the delivery of bioactive phytoconstituents, resulting in the enhancement of various pharmacokinetic properties and thereby increasing the therapeutic value of phytoconstituents. These biocompatible nanocarriers also exert low toxicity to healthy cells. This review focuses on the uses and applications of different types of nanocarriers to enhance the delivery of phytoconstituents for the treatment of various chronic diseases, along with comparisons related to bioavailability and therapeutic efficacy of nano phytoconstituents with native phytoconstituents.

Keywords:

Phytoconstituents, nanocarriers, bioavailability, chronic diseases, nanoparticles, nanomedicine.

Affiliation:

School of Pharmacy, International Medical University (IMU), Bukit Jalil, Kuala Lumpur, 57000, School of Pharmacy, International Medical University (IMU), Bukit Jalil, Kuala Lumpur, 57000, Department of Life Sciences, School of Pharmacy, International Medical University (IMU), Bukit Jalil 57000, Kuala Lumpur, Department of Pharmaceutical Technology, School of Pharmacy, International Medical University (IMU), Bukit Jalil 57000, Kuala Lumpur, Department of Pharmaceutical Technology, School of Pharmacy, International Medical University (IMU), Bukit Jalil 57000, Kuala Lumpur, Division of Applied Biomedical Science and Biotechnology, School of Health Sciences, International Medical University, Bukit Jalil 57000, Kuala Lumpur, School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur, 302017, Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW 2007, 7Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW 2007, School of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW 2007, Innovative Medicines Group, Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Kelvin Grove, Brisbane, Queensland 4059, Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW 2007, Department of Life Sciences, School of Pharmacy, International Medical University (IMU), Bukit Jalil 57000, Kuala Lumpur



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