Desu Naveen Kumar Reddy, Fu-Yung Huang*, Shao-Pin Wang and Ramya Kumar Pages 1 - 9 ( 9 )
Background: Recent studies have focused on nanoformulations of curcumin to enhance its solubility and bioavailability. The medicinal properties of curcumin-C3 complex which is a combination of three curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) is less explored.
Objective: The aim of this study was to prepare curcumin-C3 encapsulated in chitosan nanoparticles, characterize and evaluate their antioxidant and antibacterial potential.
Methods: Ionic gelation method was used to prepare curcumin-C3 nanoparticles and were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, transmission electron microscopy, nanoparticle tracking analysis. In vitro assays were performed to assess drug release, antioxidant and antibacterial activities.
Results: Curumin-C3-chitosan nanoparticle showed an increased entrapment efficiency of >90%, drug release and an improved antioxidant potential. Moreover, curumin-C3-chitosan nanoparticle showed stronger inhibition of Escherichia coli and Staphylococcus aureus.
Conclusion: Chitosan is a suitable carrier for curcumin-C3 nanoparticle and can be used as a drug delivery system in the treatment of inflammatory and bacterial diseases.
Curcumin-C3, curcumin, chitosan, nanoparticle, antioxidant, E. coli, S. aureus
Department of Chemistry, National Cheng Kung University, Tainan, Department of Chemistry, National Cheng Kung University, Tainan, Department of Chemistry, National Cheng Kung University, Tainan, Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan