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Exploring Potential of Alkaloidal Phytochemicals Targeting Neuroinflammatory Signaling of Alzheimer's Disease

Author(s):

Md. Sahab Uddin*, Md. Tanvir Kabir, Abdullah Al Mamun, Tapan Behl, Rasha A. Mansouri, Akram Ahmed Aloqbi, Asma Perveen, Abdul Hafeez and Ghulam Md Ashraf   Pages 1 - 9 ( 9 )

Abstract:


Alzheimer's disease (AD) is a chronic neurodegenerative disorder that is marked by cognitive dysfunctions and existence of neuropathological hallmarks such as amyloid plaques, and neurofibrillary tangles. It has been observed that a persistent immune response in the brain has appeared as another neuropathological hallmark in AD. The persistent activation of the microglia, the brain’s resident macrophages, and other immune cells has been shown to aggravate both tau and amyloid pathology and may consider as a connection in the AD pathogenesis. However, the basic mechanisms that link immune responses in the pathogenesis of AD are unclear until now since the process of neuroinflammation can have either a harmful or favorable effect on AD, according to the phase of the disease. Numerous researches recommend that nutritional fruits, as well as vegetables, possess neurodefensive properties against the detrimental effects of neuroinflammation and aging. Moreover, these effects are controlled by diverse phytochemical compounds that are found in plants and demonstrate anti-inflammatory, neuroprotective as well as other beneficial actions. In this review, we focus on the link of neuroinflammation in AD as well as highlight the probable mechanisms of alkaloidal phytochemicals to combat neuroinflammatory aspect of AD.

Keywords:

Alzheimer's disease, Amyloid plaques, Neurofibrillary tangles, Alkaloidal phytochemicals, Neuroinflammation, Immune responses

Affiliation:

Department of Pharmacy, Southeast University, Dhaka, Department of Pharmacy, BRAC University, Dhaka, Department of Pharmacy, Southeast University, Dhaka, Chitkara College of Pharmacy, Chitkara University, Punjab, Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah, Department of Biology, University of Jeddah, Jeddah, Glocal School of Life Sciences, Glocal University, Saharanpur, Glocal School of Pharmacy, Glocal University, Saharanpur, King Fahd Medical Research Center, King Abdulaziz University, Jeddah



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