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AMPK and its Activator Berberine in the Treatment of Neurodegenerative Diseases

Author(s):

Siru Qin, Huiling Tang, Wei Li, Yinan Gong, Shanshan Li, Jin Huang, Yuxin Fang, Wenjuan Yuan, Yangyang Liu, Shenjun Wang, Yongming Guo, Yi Guo and Zhifang Xu*   Pages 1 - 13 ( 13 )

Abstract:


Neurodegenerative disorders are heterogeneous diseases associated with either acute or progressive neurodegeneration, causing the loss of neurons and axons in the central nervous system (CNS), showing high morbidity and mortality, and there are few effective therapies. Here we summarized the energy sensor adenosine 5‘-monophosphate (AMP)-activated protein kinase (AMPK) and its agonist berberine can combat the common underlying pathological events of neurodegeneration including oxidative stress, neuroinflammation, mitochondrial disorder, glutamate excitotoxicity, apoptosis, autophagy disorder and neurovascular units disruption. The above actions of berberine may mainly depend on activating AMPK and its downstream targets such as mammalian target of rapamycin (mTOR), sirtuin1 (SIRT1) , nuclear factor erythroid-2 related factor-2 (Nrf2), nuclear factor-κB (NF-κB), phosphoinositide 3-kinase / protein kinase B (PI3K/Akt), nicotinamide adenine dinucleotide (NAD+ ), and p38 mitogen-activated protein kinase (p38 MAPK). It is hoped that this review will provide a powerful basis for further scientific exploration and development of berberine's therapeutic potential against neurodegeneration.

Keywords:

neurodegenerative diseases, AMPK, berberine, oxidative stress, mitochondrial disorder, glutamate excitotoxicity, neuroinflammation, apoptosis.

Affiliation:

Acupuncture Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin, Acupuncture Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin, Acupuncture Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin, Acupuncture Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin, Acupuncture Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin, Acupuncture Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin, Acupuncture Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin, The First people’s hospital of Lanzhou city, Gansu, Acupuncture Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin, Acupuncture Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin, Acupuncture Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin, College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, Acupuncture Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin



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