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Effect of Proton-Pump Inhibitors on Glucose and Insulin Metabolism on Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

[ Vol. 26 , Issue. 32 ]

Author(s):

Adriana Sánchez-García, Mario Simental-Mendía and Luis E. Simental-Mendía*   Pages 4007 - 4013 ( 7 )

Abstract:


Background: Some studies have revealed an improvement in glucose metabolism after proton-pump inhibitors (PPI) therapy; however, this evidence is inconclusive and limited.

Objective: The study aimed to examine the effect of PPI on glucose and insulin metabolism in patients with type 2 diabetes through a systematic review and meta-analysis.

Methods: Only randomized controlled trials evaluating the impact of PPI on glucose or insulin concentrations in type 2 diabetes were searched in PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases. A meta-analysis was conducted using a random-effects model and generic inverse variance method. Sensitivity analysis was performed using the leave-one-out method.

Results: Meta-analysis revealed no significant effect of PPI intervention on fasting glucose (mean difference [MD] -11.42 [95% CI, -29.68 to 6.83], I2 = 80%, p = 0.22), fasting insulin (MD 1.51 [95% CI, -0.36 to 3.37], I2 = 32%, p = 0.11), HOMA-IR (MD -0.16 [-0.98 to 0.65], I2 = 0%, p = 0.70), HOMA-β (MD 19.97 [-21.59 to 61.52], I2 = 71%, p = 0.35), and HbA1c concentrations (MD -0.34 [-0.99 to 0.31], I2 = 89%, p = 0.30).

Conclusion: The treatment with PPI, in the short term, had no significant effects on glucose and insulin metabolism in patients with type 2 diabetes.

Keywords:

Proton-pump inhibitors, glucose, insulin, type 2 diabetes, therapy, generic.

Affiliation:

Endocrinology Division, Hospital Universitario “Dr. Jose E. Gonzalez”, Facultad de Medicina, Universidad Autonoma de Nuevo Leon, Monterrey, NL, Department of Orthopedics and Traumatology, Hospital Universitario “Dr. Jose E. Gonzalez”, Facultad de Medicina, Universidad Autonoma de Nuevo Leon, Monterrey, NL, Unidad de Investigacion Biomedica, Delegacion Durango, Instituto Mexicano del Seguro Social, Durango



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