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Datura metel: A Review on Chemical Constituents, Traditional Uses and Pharmacological Activities

Author(s):

Waqas Alam, Haroon Khan*, Sajjad Ali Khan, Sana Nazir and Esra Kupeli Akkol   Pages 1 - 13 ( 13 )

Abstract:


Datura metel (Solanaceae) which is commonly known as thorn’s apple, Indian apple or devil’s trumpet isan annual herb of temperate zones which is distributed all over the world. D. metel belongs to the family solanaceae. From longer period of time (37 A.D), species of this family had therapeutic uses. This article is based on the review of different scientific backgrounds and studies regarding the traditional uses, phytochemistry, biochemical constituents and pharmacological uses of D. metel. This review is based on the facts of available literature review. Different researchers conducted researches and studies on D. metel and confirmed the presence of enormous chemical compounds like flavonoids, tropane alkaloids, tannins, saponins and withanolides. D. metel has been found to be pharmacologically important species because of its different pharmacological and traditional uses such as hepatoprotective, antiviral effect, antibacterial effect, anti-asthmatic, analgesic, antipyretic and nephroprotective effect, anticancer and antifungal effect. However, further in vivo and in vitro advanced studies are required to carried out for the exact pharmacological mechanisms and for basis of clinical utility.

Keywords:

Datura metel, Solanaceae; Phytochemistry, Traditional uses, Pharmacology

Affiliation:

Department of Pharmacy, Abdul Wali Khan University Mardan, 23200, Department of Pharmacy, Abdul Wali Khan University Mardan, 23200, Department of Pharmacy, Abdul Wali Khan University Mardan, 23200, Department of Pharmacy, Abdul Wali Khan University Mardan, 23200, Department of Pharmacognosy, Faculty of Pharmacy Gazi University 06330, Etiler/Ankara



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