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Marine-derived Polyaromatic Butenolides - Isolation, Synthesis and Biological Evaluations

[ Vol. 26 , Issue. 35 ]

Author(s):

Joe Bracegirdle and Robert A. Keyzers*   Pages 4351 - 4361 ( 11 )

Abstract:


Marine invertebrates, especially tunicates, are a lucrative resource for the discovery of new lead compounds for the development of clinically utilized drugs. This review describes the isolation, synthesis and biological activities of several classes of marine-derived butenolide natural products, namely rubrolides and related cadiolides and prunolides. All relevant studies pertaining to these compounds up to the end of 2019 are included.

Keywords:

Marine natural products, rubrolides, cadiolides, prunolides, antibiotics, synthesis.

Affiliation:

School of Chemical and Physical Sciences, and Centre for Biodiscovery, Victoria University of Wellington, Wellington 6012, School of Chemical and Physical Sciences, and Centre for Biodiscovery, Victoria University of Wellington, Wellington 6012



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