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Jaceosidin: A Natural Flavone with Versatile Pharmacological and Biological Activities

Author(s):

Bushra Nageen*, Azhar Rasul, Ghulam Hussain, Muhammad Ajmal Shah*, Haseeb Anwar, Syed Makhdoom Hussain, Md. Sahab Uddin, Iqra Sarfraz, Ammara Riaz and Zeliha Selamoglu   Pages 1 - 11 ( 11 )

Abstract:


Nature always remains an inexhaustible source of treasures for mankind. It remains a mystery for every challenge until the completion of the challenge. While we talk about the complicated health issues, nature offers us a great variety of chemical scaffolds and their various moieties packed in the form of natural products e.g., plants, microorganisms (fungi, algae, protozoa), and terrestrial vertebrates and invertebrates. This review article is an update about jaceosidin, a bioactive flavone, from genus Artemisia. This potentially active compound exhibits a variety of pharmacological activities including antiinflammatory, anti-oxidant, anti-bacterial, anti-allergic and anti-cancer. The bioactivities and the therapeutic action of jaceosidin, especially the modulation of different cell signaling pathways (ERK1/2, NF-κB, PI3K/Akt and ATM-Chk1/2) which become deregulated in various pathological disorders, have been focused here. The reported data suggest that the bioavailability of this anti-cancer compound should be enhanced by utilizing various chemical biology and medicinal chemistry techniques. Moreover, it is recommended that researchers and scientists should work on the mode of action of this particular flavone to precede it further as a potent anti-cancer compound.

Keywords:

Jaceosidin, Natural Products, Anti-oxidant, Anti-inflammatory, Anti-cancer, Anti-mutagenic

Affiliation:

Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad 38000, Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Department of Pharmacy, Southeast University, Dhaka, Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Department of Medical Biology, Faculty of Medicine, Nigde Ömer Halisdemir University, Nigde, Campus 51240



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