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The Effect of Dipeptidyl Peptidase-4 Inhibitors (DPP-4i) on Endothelial Function and Arterial Stiffness in Patients with Type 2 Diabetes: A Systematic Review of Randomized Placebo-controlled Trials

Author(s):

Stavroula A. Paschou, Gerasimos Siasos*, Evanthia Bletsa, Panagiota K. Stampouloglou, Evangelos Oikonomou, Alexios S. Antonopoulos, Konstantinos Batzias, Vasiliki Tsigkou, Konstantinos Mourouzis, Andromachi Vryonidou, Nikolaos Tentolouris, Manolis Vavouranakis and Dimitrios Tousoulis   Pages 1 - 9 ( 9 )

Abstract:


We systematically reviewed the literature regarding the impact of dipeptidyl peptidase-4 inhibitors (DPP-4i) on vascular function, including endothelial function and arterial stiffness (predictors of atherosclerosis progression and cardiovascular disease) in patients with type 2 diabetes mellitus (T2DM). We searched PubMed in order to identify clinical trials that investigated the effect of DPP-4i on vascular function in patients with T2DM when compared with placebo. Although 168 articles were initially found, only 6 studies (total 324 patients) investigated the effect of DPP-4i, especially linagliptin and sitagliptin, satisfied the inclusion criteria. Linagliptin enhanced endothelial function and exerted a slight beneficial effect on arterial wall properties. Sitagliptin seems to have a neutral effect on these variables. The currently available limited evidence suggests a beneficial effect of DPP-4i, especially linagliptin, on vascular function in patients with T2DM.

Keywords:

type 2 diabetes mellitus, DPP-4 inhibitors, endothelial function, arterial stiffness, cardiovascular health, molecular cardiology

Affiliation:

First Department of Cardiology, “Hippokration” General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, First Department of Cardiology, “Hippokration” General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, First Department of Cardiology, “Hippokration” General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, First Department of Cardiology, “Hippokration” General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, First Department of Cardiology, “Hippokration” General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, First Department of Cardiology, “Hippokration” General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, First Department of Cardiology, “Hippokration” General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, First Department of Cardiology, “Hippokration” General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, First Department of Cardiology, “Hippokration” General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Department of Endocrinology and Diabetes, Hellenic Red Cross Hospital, Athens, First Department of Propaedeutic and Internal Medicine, Diabetes Center, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, First Department of Cardiology, “Hippokration” General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, First Department of Cardiology, “Hippokration” General Hospital, Medical School, National and Kapodistrian University of Athens, Athens



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