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Nanomedicines in Diagnosis and Treatment of Cancer: An Update

[ Vol. 26 , Issue. 11 ]

Author(s):

Nafis Haider, Sana Fatima, Murtada Taha, Md. Rizwanullah, Jamia Firdous, Rafeeque Ahmad , Faizan Mazhar and Mohammad A. Khan*   Pages 1216 - 1231 ( 16 )

Abstract:


Nanomedicine has revolutionized the field of cancer detection and treatment by enabling the delivery of imaging agents and therapeutics into cancer cells. Cancer diagnostic and therapeutic agents can be either encapsulated or conjugated to nanosystems and accessed to the tumor environment through the passive targeting approach (EPR effect) of the designed nanomedicine. It may also actively target the tumor exploiting conjugation of targeting moiety (like antibody, peptides, vitamins, and hormones) to the surface of the nanoparticulate system. Different diagnostic agents (like contrast agents, radionuclide probes and fluorescent dyes) are conjugated with the multifunctional nanoparticulate system to achieve simultaneous cancer detection along with targeted therapy. Nowadays targeted drug delivery, as well as the early cancer diagnosis is a key research area where nanomedicine is playing a crucial role. This review encompasses the significant recent advancements in drug delivery as well as molecular imaging and diagnosis of cancer exploiting polymer-based, lipid-based and inorganic nanoparticulate systems.

Keywords:

Nanomedicine, EPR effect, passive targeting, active targeting, cancer diagnosis, multidrug resistance.

Affiliation:

Prince Sultan Military College of Health Sciences, Dhahran 34313, Department of Ilmul Saidla, National Institute of Unani Medicine, Bengaluru-560091, Prince Sultan Military College of Health Sciences, Dhahran 34313, Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, Department of Pharmacy, Institute of Bio-Medical Education and Research, Mangalayatan University, Aligarh, The New York School of Medical and Dental Assistants, Long Island City, NY 11101, Department of Bio-medical and Clinical Science, University of Milan, Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062



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