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The Influence of Vitamin D on Neurodegeneration and Neurological Disorders: A Rationale for its Physio-pathological Actions

[ Vol. 26 , Issue. 21 ]

Author(s):

Maria Morello*, Massimo Pieri, Rossella Zenobi, Alessandra Talamo, Delphine Stephan, Verena Landel, François Feron and Pascal Millet   Pages 2475 - 2491 ( 17 )

Abstract:


Vitamin D is a steroid hormone implicated in the regulation of neuronal integrity and many brain functions. Its influence, as a nutrient and a hormone, on the physiopathology of the most common neurodegenerative diseases is continuously emphasized by new studies. This review addresses what is currently known about the action of vitamin D on the nervous system and neurodegenerative diseases such as Multiple Sclerosis, Alzheimer’s disease, Parkinson’s disease and Amyotrophic Lateral Sclerosis. Further vitamin D research is necessary to understand how the action of this “neuroactive” steroid can help to optimize the prevention and treatment of several neurological diseases.

The, Influence, of, Vitamin, D, on, Neurodegeneration, and, Neurological, Disorders:, A, Rationale, for, its, Physio-pathological, Actions

Affiliation:

Clinical Biochemistry, Department of Experimental Medicine, Faculty of Medicine, University of Rome “Tor Vergata” and University Hospital of Tor Vergata, 00133 Rome, Clinical Biochemistry, Department of Experimental Medicine, Faculty of Medicine, University of Rome “Tor Vergata” and University Hospital of Tor Vergata, 00133 Rome, Clinical Biochemistry, Department of Experimental Medicine, Faculty of Medicine, University of Rome “Tor Vergata” and University Hospital of Tor Vergata, 00133 Rome, Psychiatric Clinic, University Hospital of Tor Vergata, 00133 Rome, Aix Marseille University, CNRS, INP, UMR 7051, Aix Marseille University, CNRS, INP, UMR 7051, Aix Marseille University, CNRS, INP, UMR 7051, Aix Marseille University, CNRS, INP, UMR 7051



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